Before releasing The Massacre, 50 Cent recorded a song, "Piggy Bank", which was leaked before the album's release. The song "disses" rappers including Fat Joe, Nas, and Jadakiss. Fat Joe responded with a song, "My Fo, Fo", accusing 50 Cent of taking steroids, hiding in his home, and being jealous of The Game. Jadakiss also responded with a song, "Checkmate", and said that 50 Cent was trying to "create a buzz for his new album". The music video for "Piggy Bank" portrays animated caricatures of Jadakiss (as a Ninja turtle), Fat Joe (as an overweight boxer who receives a knockout), Nas (as a kid chasing a "milkshake" truck in a Superman costume), and The Game (as Mr. Potato Head).
50 Cent spoke negatively about Bad Boy Entertainment mogul Sean "Diddy" Combs and recorded a song, "Hip-Hop", revealing the reasons behind his negative feelings: primarily, a contract dispute over Mase. In the song, he implied that Diddy knew about The Notorious B.I.G.'s murder and threatened to expose him through former associates. The feud was resolved, with both rappers appearing on MTVs TRL and Sucker Free, respectively, stating that there were no longer problems.
On February 1, 2007, Cam'ron and 50 Cent had a live argument on The Angie Martinez Show on Hot 97 radio. 50 Cent commented that Koch Entertainment was a "graveyard", meaning major record labels would not work with their artists.Cam'ron then ridiculed the record sales of G-Unit members Lloyd Banks and Mobb Deep by stating that Jim Jones outsold their albums despite being signed to an independent label and that his group, The Diplomats, had a distribution deal from several labels. Both rappers released "diss" songs with accompanying videos on YouTube. 50 Cent suggested in "Funeral Music" that Cam'ron is no longer able to lead The Diplomats and that Jim Jones should take his place. Cam'ron responded with "Curtis" and "Curtis Pt. II", in which he makes fun of 50 Cent's appearance, calling him "a gorilla, with rabbit teeth". 50 Cent responded by releasing "Hold On" with Young Buck.